•  Veröffentlichungen  1994-1997 (seit dem Umzug des Zentrums nach Rostock)
• Orginalarbeiten
• Buchkapitel, Übersichtsarbeiten, Kongressvorträge in Tagungsbänden, Sonstiges

• Ausgewählte ältere Veröffentlichungen mit Bezügen zur Mikroskopie von
  leitenden Mitarbeitern des Mikroskopiezentrums
• D.G. Weiss (vorher München)
• Hahnel (vorher München)
• W. Steffen (vorher Kaiserslautern, Minneapolis, Wien; z.Zt. London)

zu Publikationsliste der Tierphysiologie

Veröffentlichungen  1994-1997 (seit dem Umzug des Zentrums nach Rostock)

Originalarbeiten
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• Al-Haddad, A., Shonn, M.A., Redlich, B., Blocker, A., Burkhardt, J.K., Yu, H., Hammer, J.A., Weiss, D.G., Steffen, W., Griffiths, G., Kuznetsov, S.A. (1999) Interaction between phagosomes and and actin filaments in vitro: Myosin-V mediates ATP-dependent phagosome binding. J. Cell Biol., submitted
• Dopp, E., Jonas, L., Nebe, B., Budde, A., Knippel, E. (1999) Dielectric detection of changes in membrane properties and cell interior of human mesothelial cells in vitro following crocidolite asbestos exposure. submitted
• Dopp, E., Müller, J., Hahnel, C., Schiffmann, D. (1999) Induction of genotoxic effects and modulation of the intracellular calcium level in Syrian hamster embryo (SHE) fibroblasts caused by ochratoxin. Food & Chem. Tox. 37 713-721
• Dopp, E., Nebe, B., Hahnel, C., Papp, T., Alonso, B., Simkó, M., Schiffmann, D. (1995) Mineral fibers induce apoptosis in Syrian hamster embryo fibroblasts. Pathobiology 63 213-221
• Dopp, E., Papp, T., Schiffmann, D. (1997) Detection of hyperdiploidy and chromosome breakage affecting the 1(1cen-q12) region in lentigo malignant melanoma (LMN), superficial spreading melanoma (SSM) and congenital nevus (CN) cells in vitro by the multicolor FISH technique. Cancer Letters 120 157-163
• Dopp, E., Saedler, J., Stopper, H., Weiss, D.G., Schiffmann, D. (1995) Mitotic disturbances and micronucleus induction in Syrian hamster embryo fibroblast cells caused by asbestos fibers. Environmental Health Perspectives 103 268-271
• Dopp, E., Schiffmann, D. (1998) Analysis of chromosomal alterations induced by asbestos and ceramic fibers. Toxicol. Lett. 97 155-162
• Dopp, E., Schuler, M., Schiffmann, D., Eastmond, D.A. (1997) Induction of micronuclei, hyperdiploidy, and chromosomal breakage affecting the centric/pericentric regions of chromosomes 1 and 9 in human amniotic fluid cells after treatment with asbestos and ceramic fibers. Mutation Research 377 77-87
• Dopp, E., Vollmer, G., Hahnel, C., Grevesmühl, Y., Schiffmann, D. (1999) Modulation of the intracellular calcium level in mammalian cells caused by 17b-estradiol, different phytoestrogens and the antiestrogen ICI 182780. J. Steroid Biochem. Mol. Biol. 68 57-64
• Geisler, B., Weiss, D.G., Lindl, T. (1996) Video-microscopic analysis of the cytotoxic effects of 2-hydroxyethyl-methacrylate (HEMA). In-vitro Toxicology 8 367-373
• Gramowski, A., Schiffmann, D., Gross, G.W. (1999) Quantification of the neurotoxic effects of trimethyl tin chloride using spontaneously active neuronal networks cultured on multielectrode arrays. Neurotoxicology, in press
• Gross, G.W., Norton, S., Gopal, K., Schiffmann, D., Gramowski, A. (1997) Neuronal netwoks in vitro: Applications to neurotoxicology, drug development and biosensors, J. cellul. Engineering 2 138-147
• Hahnel, C., Somodi, S., Slowik, C., Weiss, D.G., Guthoff, R.F. (1997) Fluorescence microscopy and three-dimensional imaging of the porcine corneal keratocyte network. Graefe's Arch. Clin. Exp. Ophthalmol. 235 773-779
• Kriehuber, R., Simkó, M., Schiffmann, D., Trott, K.R. (1999) Delayed cytotoxic and genotoxic effects in a human cell line following X-irradiation. Int. J. Radiat. Biol. 75 1021-1027
• Kuznetsov, S.A., Rivera, D.T., Severin, F.F., Weiss, D.G., Langford, G.M. (1994) Movement of axoplasmic organelles on actin filaments from skeletal muscle. Cell Motil. Cytoskel. 28 231-242
• Langford, G.M., Kuznetsov, S.A., Johnson, D., Cohen, D.L., Weiss D.G. (1994) Movement of axoplasmic organelles on actin filaments assembled on acrosomal processes: Evidence for a barbed end-directed organelle motor. J. Cell Sci. 107 2291-2298
• Lohani, M., Dopp, E., Weiss, D.G., Schiffmann, D., Rahman, Q. (1999) Kerosene soot genotoxicity: Enhanced effects upon co-exposure with chrysotile asbestos in Syrian hamster embryo fibroblasts. Toxicol. Lett., in press
• Müller, J., Dopp, E., Hahnel, C., Weiss, D.G., Schiffmann, D. (1999) The mycotoxin ochratoxin A induces genotoxic effects and changes of the intracellular calcium level in Syrian Hamster embryo (SHE) fibroblasts. Food & Chem. Toxicol., in press
• Palazzo, R.E., Vaisberg, E.A., Weiss, D.G., Kuznetsov, S.A., Steffen, W. (1999) Dynein is required for spindle assembly in cytoplasmic extracts of Spisula solidissima oocytes. J. Cell Sci. 112 1291-1302
• Pommerenke, H., Schreiber, E., Dürr, F., Nebe, B., Hahnel, C., Möller, W., Rychly, J. (1996) Stimulation of integrin receptors using a magnetic drag force device induces an intracellular free calcium response. Europ. J. Cell Biol. 70 157-164
• Rivera, D.T., Langford, G.M., Weiss, D.G., Nelson, D.J. (1995) Regulation of the motile activity of organelles in squid axoplasm by calmodulin. Brain Res. Bulletin 37 47-52
• Rogers, S.L., Karcher, R.L., Roland, J.T., Minin, A.A., Steffen, W., Gelfand, V.I. (1999) Regulation of melanosome movement in the cell cycle by reversible association with myosin V. J. Cell Biol. 146 1265-1275
• Simkó, M., Dopp, E., Kriehuber, R. (1999) Absence of synergistic effects on micronucleus formation after exposure to electromagnetic fields and asbestos fibers in vitro. Toxicol. Lett. 108 47-53
• Simkó, M., Kriehuber, R., Lange, S. (1998) Micronucleus formation in human amnion cells after exposure to 50 Hz MF applied horizontally and vertically. Mutat. Res. 418 101-111
• Simkó, M., Kriehuber, R., Weiss, D.G., Luben, R.A. (1998) Effects of 50 Hz EMF exposure on micronucleus formation and apoptosis in transformed and non-transformed human cell lines. Bioelectromagnetics 19 85-91
• Somodi, S., Hahnel, C., Slowik, C., Richter, A., Weiss, D.G., Guthoff, R.F. (1997) Confocal in vivo microscopy and confocal laser scanning fluorescence microscopy in keratoconus. Germ. J. Ophthalmology 5 518-525
• Steffen, W., Karki, S., Vaughan, K.T., Vallee, R. B., Holzbaur, E.L.F., Weiss, D.G., Kuznetsov, S.A. (1997) The involvement of the intermediate chain of cytplasmic dynein in binding the motor complex to membraneous organelles of Xenopus oocytes. Molec. Biol. Cell 8 2077-2088
• Steinberger B., Petersen, N., Petermann, H., Weiss, D.G. (1994) Movement of magnetic bacteria in time-varying magnetic fields. J. Fluid Mechanics 273 189-211
• Tabb, J.S., Molyneaux, B.J., Cohen, D.L., Kuznetsov S.A., Langford, G.M. (1998) Transport of ER vesicles on actin filaments in neurons by myosin V. J. Cell Sci. 111 3221-3234
• Waterman-Storer, C.M., Karki, S.B., Kuznetsov, S.A., Tabb, J.S., Weiss, D.G., Langford, G.M., Holzbaur, E.L.F. (1997) The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport. Proc. Natl. Acad. Sci. USA 94 12180-12185
  

• Guthoff, R.F., Weiss, D.G., eds. (1996) Symposium on Confocal Imaging of Living Tissue, Rostock June 21. - 22., 1996, Abstract Booklet, Universität Rostock, 33 S.
• Kuznetsov, S.A., Weiss, D.G. (1998) The use of acrosomal processes in actin motility studies. In: Cell Biology: A Laboratory Handbook, J.E. Celis, Ed., Academic Press, 2nd ed., Vol. 2, pp. 344-349
• Schiffmann, D., Rahman, Q. (1997) Chromosomal changes induced by asbestos fibers: An overview. In: Sourcebook on Asbestos Diseases, G.A. Peters and B.J. Peters Eds., The Michie Company, Charlottesville, USA, Vol. 14, pp. 41-59
• Steffen, W. (1999) Tat-mediated delivery of antibodies to cultured cells. Meth. Molec. Biol., Vol. .., Cytoskeleton: Methods and Protocols, R.H. Gavin, Ed., Humana Press (in press)
• Steffen, W., Hodgkinson, J.L. (1999) Direct labeling of components in protein complexes by immuno-electron microscopy. Meth. Molec. Biol., Vol. .., Cytoskeleton: Methods and Protocols, R.H. Gavin, Ed., Humana Press (in press)
• Steffen, W., Hodgkinson, J.L. (1999) Site-directed antibodies as tools for investigating structure and function of cytoskeleton proteins. Meth. Molec. Biol., Vol. .., Cytoskeleton: Methods and Protocols, R.H. Gavin, Ed., Humana Press (in press)
• Steffen, W., Langford, G.M., Weiss, D.G., Kuznetsov, S.A. (1997) Inhibition of microtubule-dependent minus-end directed transport of axoplasmic organelles by a dynein intermediate chain specific antibody. Biol. Bulletin (Woods Hole) 193 221-222
• Steffen, W., Weiss, D.G. (1999) Marktübersicht Biological Imaging. Ein Bild sagt mehr als 1000 Worte. BioSpektrum 5 (2) 118-142
• Suddith, A.W., Vaisberg, E.A., Kuznetsov, S.A., Steffen, W., Rieder, C.L., Palazzo, R.E. (1999) Centriole duplication, centrosome maturation, and spindle formation in lysates of Spisula solidissima oocytes. Meth. Molec. Biol., Vol. .. Cytoskeleton: Methods and Protocols, R.H. Gavin, Ed., Humana Press (in press)
• Weiss, D.G. (1994) Video-enhanced contrast microscopy In: Cell Biol.: A Laboratory Handbook J.E. Celis, Ed., Academic Press, pp. 77-85
• Weiss, D.G. (1998) Video-enhanced contrast microscopy. In: Cell Biology: A Laboratory Handbook, J.E. Celis, Ed., Academic Press, 2nd ed., Vol. 3, 99-108
• Weiss, D.G., ed. (1997) 5. Kolloquium des DFG-Schwerpunktprogramms "Neue mikroskopische Techniken für Biologie und Medizin", Rostock 4.-6.3.1997, Abstraktband, Universität Rostock, 35 S.
• Weiss, D.G., Gross, G.W. (1996) Neuronale Netzwerke in Kultur auf Multi-Elektrodenarrays. In: Fachtagung Informationstechnik und Biotechnologie. Projektträger des BMBF für Informationstechnik bei der DLR, Bonn 3.3.1996, Hrsg. BMBF, Bonn, S. 35-66
• Weiss, D.G., Lichtscheidl, I.K. (1995) The cytoplasm of Allium cepa inner epidermal cells as observed by AVEC-DIC microscopy (Begleitveröffentlichung zum wiss. Film C 2117 (1988) des ÖWF). Wiss. Film (Wien) 47 79-93
• Weiss, D.G., Maile, W., Wick, R.A., Steffen, W. (1999) Video microscopy. (Chapter 3) In: Light Microscopy in Biology, A Practical Approach, 2nd. ed., A.J. Lacey (ed.). Oxford University Press, Oxford, pp. 73-149
• Weiss, D.G., Steffen, W. (1998) Marktübersicht Lichtmikroskopie. Lichtmikroskopie heute: Die lebende Zelle als Meßküvette. BioSpektrum 4 (5) 67-81
• Weiss, D.G., Tychinsky, V.P., Steffen, W., Budde, A. (1999) Digital light microscopy techniques for the study of living cytoplasm. In: Image Analysis in Biology, 2nd ed., D.-P. Häder, Ed., CRC Press, Boca Raton, in press

• Allen, R.D., D.G. Weiss, J. Hayden, D.T. Brown, H. Fujiwake, M. Simpson (1985) Gliding movement of and bidirectional organelle transport along single native microtubules from squid axoplasm: Evidence for an active role of microtubules in cytoplasmic trans-port. J. Cell Biol. 100 1736-1752
• Bastmeyer, M., Fuge, H. (1987) Arrangement and dynamics of spindle structures in crane fly spermatocytes seen with video-enhanced contrast differential interference contrast microscopy. Chromosoma 95 51-56
• Dittmann, F., D.G. Weiss, A. Münz (1987) Movement of mitochondria in the ovarian trophic cord of Dysdercus intermedius (Heteroptera) resembles nerve axonal transport. Roux's Arch. Develop. Biol. 196 407-413
• Kuznetsov S.A., Langford G.M., Weiss D.G. (1992) Actin-dependent organelle movement in squid axoplasm. Nature 356 722-725
• Lichtscheidl, I.K., D.G. Weiss (1988) Visualization of submicroscopic structures in the cytoplasm of Allium cepa inner epidermal cells by video-enhanced contrast light microscopy. Eur. J. Cell Biol. 46 376-382
• Maile, W., T. Lindl, D.G. Weiss (1989) New methods for cytotoxicity testing: Quantitative video microscopy of intracellular motion and mitochondria-specific fluorescence. Molec. Toxicol. 1 427-437
• Schiffmann, D., Tas, P., Koschel, K. (1989) Does Diethylstilbestrol (DES) change the stress fiber organization in C6 rat glioma cells? Molec. Toxicol. 1 407-418
• Seitz-Tutter, D., G.M. Langford, D.G. Weiss (1988) Dynamic instability of native microtubules from squid axons is rare and in-dependent of gliding and vesicle transport. Exptl. Cell Res. 178 504-511
• Weiss D.G. (1989) Videomicroscopic measurements in living cells: Dynamic determination of multiple end points for in vitro toxicology. Molec. Toxicol. 1 465-488
• Weiss, D.G., F. Keller, J. Gulden, W. Maile (1986) Towards a new classification of intracellular particle movements based on quantitative analyses. Cell Motil. Cytoskel. 6 128-135
• Weiss, D.G., G.M. Langford, D. Seitz-Tutter (1992) Analysis of the gliding, fishtailing, and circling motions of native microtubules. Acta histochem. S41 81-105
• Weiss, D.G., G.M. Langford, D. Seitz-Tutter, F. Keller (1988) Dynamic instability and motile events of native microtubules from squid axoplasm. Cell Motil. Cytoskel. 10 285-296

• Weiss, D.G. (1991) Video-microscopic techniques to study axonal transport, neuronal fine structure and cytochemical parameters in live neurons. In: Recent Advances in Neurocytochemical Methods. A. Calas and D. Eugene, Eds., NATO ASI Series, Vol. H 58, Springer Berlin, pp. 59-73
• Weiss, D.G., Galfe, G. (1991) Video-microscopic techniques to study the living cytoplasm. In: Image Analysis in Biology, D.-P. Häder, Ed., CRC Press, Boca Raton FL, pp. 135-158
• Weiss, D.G., Galfe, G., Gulden, J., Seitz-Tutter, D., Langford, G.M., Struppler, A., Weindl, A. (1990) Motion analysis of intracellular objects: Trajectories with and without visible tracks. In: Biological Motion, W. Alt and G. Hoffmann, Eds., Lecture Notes in Biomathematics, Vol. 89, Springer-Verlag Berlin, pp. 95-116
• Weiss, D.G., Maile, W. (1993) Principles, practice, and applications of video-enhanced contrast microscopy. In: Electronic Light Microscopy: The Principles and Practice of Video-Enhanced Contrast, Digital Intensified Fluorescence and Confocal Laser Scanning Microscopy. D.M. Shotton, Ed., Wiley-Liss, New York, pp. 105-140
• Weiss, D.G., Maile, W., Wick, R.A. (1989) Video microscopy. (Chapter 8) In: Light Microscopy in Biology. - A Practical Approach, A.J. Lacey, Ed., IRL Press, Oxford, pp. 221-278
• Weiss, D.G., Meyer, M.A., Langford, G.M. (1990) Studying axoplasmic transport by video microscopy and using the squid giant axon as a model system. (Chapter 15) In: Squid as Experimental Animals, D.L. Gilbert, W.J. Adelman, J. Arnold, Eds., Plenum Press, New York, pp. 303-321

• Allen, R.D., Weiss, D.G. (1986) Mikrotubuli als intrazelluläres Transportsystem. Spektrum der Wissenschaft, April 1987, 76-85
• Leterrier, J.-F., Eyer, J., Weiss, D.G., Lindén, M. (1991) In vitro studies of the physical interactions between neurofilaments, microtubules and mitochondria isolated from the central nervous system. In: The Living Cell in Four Dimensions, G. Paillotin (ed.), Amer. Inst. of Physics (AIP) Conference Proceedings, Vol. 226, pp. 91-105
• Maile, W., Weiss, D.G. (1992) Videomikroskopie als Weg zur Reduzierung von Tierversuchen in Pharmakologie und Toxikologie. In: Schöffl, H., Schulte-Hermann, R., Tritthart, H.A. (eds.) Möglichkeiten und Grenzen der Reduktion von Tierversuchen. Springer-Verlag, Wien, S. 68-75
• Petermann, H., Weiss, D.G., Bachmann, L., Petersen, N. (1990) Motile behaviour and measurement of the magnetic moment of magnetotactic bacteria in rotating magnetic fields. In: Biological Motion, W. Alt and G. Hoffmann, Eds., Lecture Notes in Biomathematics, Vol. 89, Springer-Verlag Berlin, pp. 387-395
• Petersen, N., Weiss, D.G., Vali, H. (1989) Magnetic bacteria in lake sediments: Ultrastructure, magnetic moment and motility. In: Geomagnetism and Palaeomagnetism, F.J. Lowes et al. Eds., Kluwer Academic Publishers, pp. 231-241
• Weiss, D.G. (1986) Visualization of the living cytoskeleton by video-enhanced microscopy and digital image processing. In: The Cytoskeleton: Cell Function and Organization, J. Cell Sci., Suppl.5, C. Lloyd, J. Hyams, R. Warn, Eds., pp. 1-15
• Weiss, D.G., Buchner, K. (1988) Axoplasmic transport in olfactory receptor neurons. In: Molecular Neurobiology of the Olfactory System, F.L. Margolis, T.V. Getchell, Eds., Plenum Press, New York, pp. 217-236
• Weiss, D.G., Lichtscheidl, I. (1988) The cytoplasm of Allium cepa inner epidermis cells observed by AVEC-DIC microscopy. Forschungsfilm, Österr. Inst. f. d. wiss. Film ÖWF, Wien, Film C2117, 16 mm, 12 min, Lichtton, Encyclopedia Cinematographica (Begleittext 14 S.)
• Weiss, D.G., Maile, W. (1986) Ein Blick in die lebende Zelle. Katalog zur Ausstellung des Boehringer Ingelheim Fonds, Stuttgart, 43 S. (Die Ausstellung wurde in Stuttgart, Freiburg und München gezeigt.)
• Weiss, D.G., Maile, W., Galfe, G.G. (1992) Videomikroskopische Meßverfahren zur Erfassung der Wirkung von Schadstoffbelastungen. Materialien des Bayer. Staatsministeriums für Landesentwicklung und Umweltfragen, Band 93, 127 S.
• Weiss, D.G., Seitz-Tutter, D., Langford, G.M. (1990) Motility in extruded squid axoplasm. Cell Motil. Cytoskel., Video Supplement 2, Video Tape, mit Begleittext (Text: Cell Motil. Cytoskel. 17 356-372)

C. Hahnel (vorher München)

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• Berninger, B., Garcia, D.E., Inagaki, N., Hahnel, C., Lindholm, D. (1993) BDNF and NT-3 induce intracellular Ca²+ elevation in hippocampal neurones. NeuroReport 4 1303-1306
• Hahnel, C. (1992) Quantitative microinjection. In: Practical Electrophysiological Methods. Kettenmann & Grantyn, Eds., Wiley-Liss, New York, pp.316-320
• Hahnel, C., Gottmann, K., Wittinghofer, A., Lux, H.D. (1992) p21ras oncogene protein selectively increases low voltage-activated Ca²+ current density in embryonic chick dorsal root ganglion neurons. Europ. J. Neurosci. 4 361-368
• Neumann, H., Boucraut, J., Hahnel, Ch., Misgeld, T., Wekerle, H. (1996) Neuronal control of MHC class II inducibility in rat astrocytes and microglia. Europ. J. Neurosci. 8 2582-2590
• Stöckel, J., Meinl, E., Hahnel, C., Malotka, J., Seitz, R., Drexler, K., Wekerle, H., Dornmair, K. (1994) Refolding of human class II major histocompatibility complex molecules isolated from Escherichia coli. J. Biol. Chem. 269 29571-29578

W. Steffen ( vorher Kaiserslautern, Minneapolis, Wien, z.Zt. am King's College, London)

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• Steffen, W., Fuge, H. (1985) Three-dimensional architecture of chromosome fibres in crane fly: Amphitelic autosomal univalents in late prometaphase. Cytobios 43 199-212
• Steffen, W., Fuge, H., Dietz, R., Bastmeyer, M., Müller, G. (1986) Aster-free spindle pole in insect spermatocytes: Evidence for chromosome induced spindle formation? J. Cell Biol. 102 1679-1688
• Steffen, W. (1986) Three-dimensional architecture of chromosome fibres in crane fly: co-oriented autosomal bivalents and amphitelic sex univalents. Chromosoma 94 107-114
• Steffen, W. (1986) Relationship between the arrangement of microtubules and chromosome behaviour of syntelic autosomal univalents during prometaphase in crane fly spermatocytes. Chromosoma 94 412-418
• Bastmeyer, M., Steffen, W., Fuge, H. (1986) Immunostaining of spindle components in tipulid spermatocytes using a serum against pericentriolar material. Europ. J. Cell Biol. 42 305-310
• Linck, R.W., Goggin, M.J., Norrander, J.M., Steffen, W. (1987) Characterization of antibodies as probes for structural and biochemical studies of tektins from ciliary and flagellar microtubules. J Cell Sci. 88 453-466
• Steffen, W., Linck, R.W. (1988) Evidence for tektins in centrioles and axonemal microtubules. Proc. Natl. Acad. Sci. (USA) 85 2643-2647
• Steffen, W., Linck, R.W. (1988) Are tektins, intermediate filament-like proteins, part of axonemal microtubules, basal bodies and centrioles? Cell Motil. Cytoskel. 10 346-347
• Linck, R.W., Amos, L.A., Amos, W.B., Norrander, J.M., Steffen, W., Stephens, R.E. (1988) Tektins: Proteins forming integral filaments within certain microtubules. Cell Motil. Cytoskel. 11 207-208
• Steffen, W., Linck, R.W. (1989) Tektins in ciliary and flagellar microtubules and their association with other cytoskeletal systems. In: Cell Movement, vol. 2, Kinesin, Dynein and Microtubule Dynamics. eds. FD Warner, JR McIntosh. (Alan Liss), pp 67-81
• Steffen, W., Linck, R.W. (1989) Multiple Immunoblot: A sensitive technique to stain proteins and detect multiple antigens on a single 2-D replica. Electrophoresis 10 714-718
• Steffen, W., Linck, R.W. (1989) Relationship between tektins and intermediate filament proteins: an immunological study. Cell Motil. Cytoskel. 14 359-371
• Steffen, W., Linck, R.W. (1992) Evidence for a non-tubulin spindle matrix and spindle components immunologically related to tektin filaments. J. Cell Sci. 101 809-822
• Steffen, W., Fajer, E., Linck, R.W. (1994) Centrosomal components immunologically related to tektins from ciliary and flagellar microtubules. J. Cell Sci. 107 2095-2105
• Steffen, W., Hodgkinson, J.L., Wiche, G. (1996) Immunogold localisation of the intermediate chain within the protein complex of cytoplasmic dynein. J. Struct. Biol. 117 227-235